Serotonin Transporter
5-HTT; SERT; SLC6A4
Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.
Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.
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Serotonin Transporter Inhibitors
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Serotonin Transporter Agonists
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Serotonin Transporter Antagonists
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Serotonin Transporter Activators
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Serotonin Transporter Modulators
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Serotonin Transporter Controls
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Serotonin Transporter Substrates
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Serotonin Transporter Ligands
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Serotonin Transporter Related Products (317)
Related Products (317)
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Antibodies (3)
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SLV310
0 ImagesCat. No.: HY-106194CAS No.: 264869-71-8SLV310 is an orally active dopamine D2 receptor antagonist (Ki: 5 nM) and serotonin reuptake receptor inhibitor. SLV310 antagonizes Apomorphine (HY-12723) induced climbing behaviour and 5-HTP (HY-N0122) induced serotonin syndrome like behaviour in mice (ED50: 5.6 and 5.9 mg/kg, p.o.). SLV310 is an antipsychotic compound and can be used for schizophrenia research.
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Z8779877149
0 ImagesCat. No.: HY-181878Synonyms: Z7149Z8779877149 (Z7149) is a blood-brain barrier-permeable multi-target ligand that targets SERT (Ki=198 nM), α2A adrenergic receptor (Ki=180 nM; EC50=440 nM) and 5-HT2A receptor (EC50=172 nM, Emax=76%). Z8779877149 inhibits 5-HT reuptake and activates Gi and Gq protein signaling pathways, respectively. Z8779877149 effectively alleviates pain responses as well as depression- and anxiety-like behaviors, while exhibiting favorable safety without inducing sedation or motor impairment. Z8779877149 is available for the research of pain, depression and anxiety disorders.
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(±)-Duloxetine hydrochloride
0 ImagesCat. No.: HY-B0161ECAS No.: 947316-47-4Synonyms: (Rac)-Duloxetine hydrochloride(±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride. Duloxetine hydrochloride, a serotonin-norepinephrine reuptake inhibitor, can be used for diabetic neuropathic pain and fibromyalgia as well as major depressive disorder research.
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PH-064 (tetra(hydrochloride))
0 ImagesCat. No.: HY-10499ACAS No.: 2489449-03-6Synonyms: BIM-46187 tetrahydrochloridePH-064 tetrahydrochloride (BIM-46187 tetrahydrochloride) is an orally active inhibitor of the heterotrimeric G-protein complex. PH-064 tetrahydrochloride inhibits SERT activity and attenuates shear stress-induced Akt phosphorylation. PH-064 tetrahydrochloride has potent anti-hyperalgesia activity. PH-064 tetrahydrochloride inhibits G protein-coupled receptor-dependent tumorigenesis. PH-064 tetrahydrochloride can be used in the study of pain (e.g., inflammatory pain, neuropathic pain), GPCR-dependent tumors, and inflammatory lung injury.
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iso-WAY-260022
0 ImagesCat. No.: HY-10427ACAS No.: 1214914-38-1Synonyms: iso-NRI-022iso-WAY-260022 (Compound 13R) is an orally active, brain-penetrant and selective norepinephrine transporter (hNET) inhibitor with an IC50 value of 140 nM. iso-WAY-260022 also shows inhibitory effects on human serotonin (hSERT) and dopamine transporters (hDAT). iso-WAY-260022 inhibits norepinephrine reuptake and increases hypothalamic norepinephrine levels to regulate thermoregulatory center function. iso-WAY-260022 is promising for research of vasomotor symptoms, such as menopausal hot flushes, night sweats.
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Dapoxetine-d6 hydrochloride
0 ImagesCat. No.: HY-B0304AS1CAS No.: 1246814-76-5Synonyms: LY-210448-d6 hydrochlorideDapoxetine-d6 (LY-210448-d6) hydrochloride is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI)
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(rac)-Dapoxetine-d6 hydrochloride
0 ImagesCat. No.: HY-B0304AS2(rac)-Dapoxetine-d6 (hydrochloride) is the deuterium labeled (rac)-Dapoxetine hydrochloride.
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Atomoxetine-d7 hydrochloride
0 ImagesCat. No.: HY-17385S1Synonyms: Tomoxetine-d7 hydrochloride; (R)-Tomoxetine-d7 hydrochlorideAtomoxetine-d7 hydrochloride (Tomoxetine-d7 hydrochloride) is the deuterium labeled Atomoxetine hydrochloride (HY-17385). Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.
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Venlafaxine-d6-1
0 ImagesCat. No.: HY-B0196S1CAS No.: 940297-06-3Synonyms: Wy 45030-d6-1Venlafaxine-d6-1 is deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant.
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Tesofensine-d5
0 ImagesCat. No.: HY-14472SSynonyms: NS-2330-d5Tesofensine-d5 (NS-2330-d5) is the deuterium labeled Tesofensine (HY-14472). Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC50=6.5 nM), norepinephrine (NE;IC50=1.7 nM), and serotonin (5-HT;IC50=11 nM), and with potentials as an anti-obesity agent. Tesofensine is a CNS acting anti-obesity agent.
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Desvenlafaxine-d10
0 ImagesCat. No.: HY-B0602S3CAS No.: 1062607-49-1Desvenlafaxine-d10 is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter.
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Clovoxamine
0 ImagesCat. No.: HY-129985CAS No.: 54739-19-4Synonyms: DU23811Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant.
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Dextromilnacipran hydrochloride
0 ImagesCat. No.: HY-14794BCAS No.: 175131-61-0Synonyms: (1R,2S)-Milnacipran hydrochloride; F2696 hydrochlorideDextromilnacipran ((1R,2S)-Milnacipran; F2696) hydrochloride is an orally active Serotonin (HY-B1473A)/Noradrenaline (HY-13715) transporter inhibitor. Dextromilnacipran hydrochloride inhibits Serotonin and Noradrenaline reuptake. Dextromilnacipran hydrochloride can be used for the research of depression, fibromyalgia.
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SRI-29574
0 ImagesCat. No.: HY-126158CAS No.: 1928712-46-2SRI-29574 is an allosteric modulator of the dopamine transporter (DAT). SRI-29574 partially inhibits the uptake of the DAT (IC50=2.3 nM) and also partially inhibits the uptake of the serotonin transporter (SERT) and norepinephrine transporter (NET). SRI-29574 may serve as a useful probe to study the function and regulatory mechanisms of DAT.
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BGC-201259
0 ImagesCat. No.: HY-107047CAS No.: 444667-97-4Synonyms: RS-1259BGC-201259 (RS-1259) is an orally active inhibitor that simultaneously targets acetylcholinesterase (AChE) (IC50 = 101 nM) and serotonin transporter (SERT) (IC50 = 42 nM). BGC-201259 inhibits 5-HT receptor with an IC50 of 90 nM. BGC-201259 exhibits strong weak activity against the NA transporter (IC50 = 7.7 μM), L-type calcium channel (IC50 = 3.6 μM), σ receptor (IC50 = 2 μM), and sodium channel (IC50 = 5.1 μM). BGC-201259 demonstrates synergistic potential in improving cognitive and emotional symptoms by balancing the inhibition of these two targets. BGC-201259 can be used in research on Alzheimer's disease.
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Moleroxetine
0 ImagesCat. No.: HY-187799CAS No.: 1417918-09-2Moleroxetine (Compound I-b) is a 5-hydroxytryptamine/norepinephrine dual reuptake inhibitor. Moleroxetine can be used in studies related to major depressive disorder.
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MADAM
0 ImagesCat. No.: HY-W792458CAS No.: 411208-45-2MADAM exhibits high affinity and selectivity for 5-HTT with a Ki value of 1.6 nM. MADAM has the potential to serve as a PET radiotracer for visualizing the serotonin transporter.
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CSP-2503
0 ImagesCat. No.: HY-180372CAS No.: 581813-10-7CSP-2503 is a potent and selective 5-HT1A receptor agonist , with an EC50 of 0.15 μM and a Ki of 4.1 nM. CSP-2503 exhibits excellent selectivity over α1-adrenoceptors (Ki > 1000 nM), 5-HT4 receptors, and benzodiazepine receptors. CSP-2503 inhibits cAMP increase in vitro and exhibits anxiolytic activity in vivo. CSP-2503 can be used for the research of anxiety-related disorders.
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DOV-216,303
0 ImagesCat. No.: HY-W061043CAS No.: 86215-36-3DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats.
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Desmethyl Sibutramine hydrochloride (Standard)
0 ImagesSynonyms: N-Desmethylsibutramine hydrochloride (Standard)Desmethyl Sibutramine (hydrochloride) (Standard) is the analytical standard of Desmethyl Sibutramine (hydrochloride). This product is intended for research and analytical applications. Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant.
